Gr-1+CD11b+ cells induced by Cholic acids conjugates protect against mouse sepsis
Sooghee Chang
Department of Biomedical Sciences, Seoul National University College of Medicine, Gwanak _ 599 Gwanak-ro, Gwanak-gu, Seoul 151-742, Korea
Abstract:
Cholic acids conjugates (glycine-conjugated cholic acids (CCA) and taurine-CCA) protected against both LPS induced sepsis and polymicrobial sepsis induced by CLP. They increased the splenic Gr-1+CD11b+ cell population, known as immunosuppressive myeloid-derived suppressor cell (MDSC).
To explore their antiseptic effect, Gr-1+CD11b+ cells purified from CCA treated sepsis mice were adoptively transferred to sepsis mice. 80% of mice had survivaled for 14 days after adoptive transfer, in comparing with 10 % survival of control group.
Even though More studies to elucidate the mechanism of action are needed, CCA might protect against sepsis by induction of Gr-1+CD11b+ cells
